XERARDO XUSTO
GARCIA MERA
University professor
MARIA OLGA
CAAMAÑO SANTOS
Researcher in the period 1991-2021
Publications by the researcher in collaboration with MARIA OLGA CAAMAÑO SANTOS (46)
2021
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3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480
2020
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Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists
Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739
2019
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Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition
Journal of Medicinal Chemistry, Vol. 62, Núm. 20, pp. 9315-9330
2018
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(±)-3,5-bis(substitutedmethyl)pyrrolidines: Application to the synthesis of analogues of glycine-l-proline-l-glutamic acid (GPE)
Current Organic Synthesis, Vol. 15, Núm. 2, pp. 230-236
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One-pot preparation and characterisation of five-membered cyclic alcohols
Letters in Organic Chemistry, Vol. 15, Núm. 6, pp. 546-550
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Perturbation Theory/Machine Learning Model of ChEMBL Data for Dopamine Targets: Docking, Synthesis, and Assay of New l -Prolyl- l -leucyl-glycinamide Peptidomimetics
ACS Chemical Neuroscience, Vol. 9, Núm. 11, pp. 2572-2587
2017
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Advances towards the synthesis and characterization of five-membered cyclic alcohols and ketones
Chemical Data Collections
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Multi-target mining of alzheimer disease proteome with Hansch’s QSBR-perturbation theory and experimental-theoretic study of new thiophene isosters of rasagiline
Current Drug Targets, Vol. 18, Núm. 5, pp. 511-521
2016
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Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives
Neuropharmacology, Vol. 103, pp. 270-278
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Experimental-theoretic approach to drug-lymphocyte interactome networks with flow cytometry and spectral moments perturbation theory
Current Pharmaceutical Design, Vol. 22, Núm. 33, pp. 5114-5119
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Novel l-prolyl-l-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R
Organic and Biomolecular Chemistry, Vol. 14, Núm. 47, pp. 11065-11069
2015
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A click chemistry approach to the synthesis of 3′-deoxy-2′-substituted carbanucleoside precursors
Tetrahedron, Vol. 71, Núm. 2, pp. 324-331
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Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity
European Journal of Medicinal Chemistry, Vol. 98, pp. 212-220
2014
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Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates
International Journal of Molecular Sciences, Vol. 15, Núm. 9, pp. 17035-17064
2013
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Model for high-throughput screening of multitarget drugs in chemical neurosciences: Synthesis, assay, and theoretic study of rasagiline carbamates
ACS Chemical Neuroscience, Vol. 4, Núm. 10, pp. 1393-1403
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Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of l-prolyl-l-leucyl-glycinamide (PLG) modified in the l-proline or l-proline and l-leucine scaffolds
European Journal of Medicinal Chemistry, Vol. 69, pp. 146-158
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TOPS-MODE model of multiplexing neuroprotective effects of drugs and experimental-theoretic study of new 1,3-rasagiline derivatives potentially useful in neurodegenerative diseases
Bioorganic and Medicinal Chemistry, Vol. 21, Núm. 7, pp. 1870-1879
2012
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3D MI-DRAGON: New model for the reconstruction of US FDA drug- target network and theoretical-experimental studies of inhibitors of rasagiline derivatives for AChE
Current Topics in Medicinal Chemistry, Vol. 12, Núm. 16, pp. 1843-1865
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A route to selective functionalization of polyhydroxypyrrolidines
Tetrahedron Letters, Vol. 53, Núm. 9, pp. 1029-1032
2011
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MIND-BEST: Web server for drugs and target discovery; Design, synthesis, and assay of MAO-B inhibitors and theoretical-experimental study of G3PDH protein from trichomonas gallinae
Journal of Proteome Research, Vol. 10, Núm. 4, pp. 1698-1718