José Manuel
Brea Floriani
Profesor titular de universidade
![Foto de José Manuel](/img/nophoto.png)
![Foto de Uppsala University](/img/noimage_org.png)
Uppsala University
Upsala, SueciaPublicacións en colaboración con investigadores/as de Uppsala University (12)
2024
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
Molecules, Vol. 29, Núm. 11
2022
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A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5
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Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3Antagonists
ACS Medicinal Chemistry Letters, Vol. 13, Núm. 2, pp. 243-249
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Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists
Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106
2021
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3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480
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Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology
Angewandte Chemie - International Edition, Vol. 60, Núm. 33, pp. 18022-18030
2020
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Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists
Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739
2019
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Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition
Journal of Medicinal Chemistry, Vol. 62, Núm. 20, pp. 9315-9330
2017
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3-Oxopyridazin-5-yl-Chalcone Hybrids: Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation
ChemistrySelect, Vol. 2, Núm. 17, pp. 4920-4933
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Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
Journal of Medicinal Chemistry, Vol. 60, Núm. 17, pp. 7502-7511
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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Journal of Medicinal Chemistry, Vol. 60, Núm. 8, pp. 3372-3382
2010
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Phe369(7.38) at human 5-HT 7 receptors confers interspecies selectivity to antagonists and partial agonists
British Journal of Pharmacology, Vol. 159, Núm. 5, pp. 1069-1081