José Manuel
Brea Floriani
Profesor titular de universidade
![Foto de José Manuel](/img/nophoto.png)
![Foto de Universidade Do Porto](/img/noimage_org.png)
Universidade Do Porto
Oporto, PortugalPublicacións en colaboración con investigadores/as de Universidade Do Porto (12)
2023
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8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies
European Journal of Medicinal Chemistry, Vol. 248
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Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors
ACS Medicinal Chemistry Letters, Vol. 14, Núm. 12, pp. 1656-1663
2021
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Discovery of New Potent Positive Allosteric Modulators of Dopamine D2Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide
Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6209-6220
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Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML)
ACS Chemical Neuroscience, Vol. 12, Núm. 1, pp. 203-215
2019
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Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R
ACS Chemical Neuroscience, Vol. 10, Núm. 8, pp. 3690-3702
2017
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Cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers
Organic Letters, Vol. 19, Núm. 10, pp. 2560-2563
2013
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Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of l-prolyl-l-leucyl-glycinamide (PLG) modified in the l-proline or l-proline and l-leucine scaffolds
European Journal of Medicinal Chemistry, Vol. 69, pp. 146-158
2010
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Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists
Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 5, pp. 2001-2009
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Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists
European Journal of Medicinal Chemistry, Vol. 45, Núm. 7, pp. 2884-2892
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Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors
Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 6, pp. 2081-2088
2009
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Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists
Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 18, pp. 6755-6760
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Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A2B receptor antagonists
Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 9, pp. 3426-3432