José Manuel
Brea Floriani
Profesor titular de universidade
![Foto de Jhonny Alberto](/img/nophoto.png)
Jhonny Alberto
Azuaje Guerrero
Publicacións nas que colabora con Jhonny Alberto Azuaje Guerrero (16)
2024
2023
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Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912
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Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
Biomedicine and Pharmacotherapy, Vol. 164
2022
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A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5
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Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3Antagonists
ACS Medicinal Chemistry Letters, Vol. 13, Núm. 2, pp. 243-249
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Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists
Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106
2021
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3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480
2020
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Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists
Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739
2019
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Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition
Journal of Medicinal Chemistry, Vol. 62, Núm. 20, pp. 9315-9330
2018
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Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
Annals of Neurology, Vol. 84, Núm. 2, pp. 260-273
2017
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Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases
Journal of Cheminformatics, Vol. 9, Núm. 1
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Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Scientific Reports, Vol. 7, Núm. 1
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Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
Journal of Medicinal Chemistry, Vol. 60, Núm. 17, pp. 7502-7511
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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Journal of Medicinal Chemistry, Vol. 60, Núm. 8, pp. 3372-3382
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Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A2B adenosine receptor antagonists
Chemistry of Heterocyclic Compounds, Vol. 53, Núm. 3, pp. 316-322
2013
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Discovery of 3,4-dihydropyrimidin-2(1 H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists
ACS Medicinal Chemistry Letters, Vol. 4, Núm. 11, pp. 1031-1036