Publikationen, an denen er mitarbeitet José Manuel Otero Casas (30)

2023

  1. Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight †

    Frontiers in Molecular Biosciences, Vol. 10

  2. β-Peptides incorporating polyhydroxylated cyclohexane β-amino acid: synthesis and conformational study

    Organic and Biomolecular Chemistry, Vol. 21, Núm. 42, pp. 8535-8547

2020

  1. Highly functionalized cyclic and bicyclic β−amino acids from sugar β−nitroesters

    Tetrahedron, Vol. 76, Núm. 3

2019

  1. Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme

    Organic Chemistry Frontiers, Vol. 6, Núm. 17, pp. 3127-3135

2016

  1. 6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology

    Chemistry - A European Journal, Vol. 22, Núm. 35, pp. 12557-12565

  2. Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter

    ACS Synthetic Biology, Vol. 5, Núm. 10, pp. 1136-1145

2015

  1. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

    Journal of the American Chemical Society, Vol. 137, Núm. 29, pp. 9333-9343

  2. Irreversible covalent modification of type i dehydroquinase with a stable Schiff base

    Organic and Biomolecular Chemistry, Vol. 13, Núm. 3, pp. 706-716

2014

  1. Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors

    Journal of Medicinal Chemistry, Vol. 57, Núm. 8, pp. 3494-3510

  2. Insights into substrate binding and catalysis in bacterial type i dehydroquinase

    Biochemical Journal, Vol. 462, Núm. 3, pp. 415-424

2013

  1. Design, synthesis, and structural analysis of turn modified cyclo-(αβ3αβ2α)2 peptide derivatives toward crystalline hexagon-shaped cationic nanochannel assemblies

    Crystal Growth and Design, Vol. 13, Núm. 10, pp. 4355-4367

  2. Mechanistic basis of the inhibition of type II dehydroquinase by (2 S)- and (2 R)-2-benzyl-3-dehydroquinic acids

    ACS Chemical Biology, Vol. 8, Núm. 3, pp. 568-577

  3. Mycobacterium tuberculosis shikimate kinase inhibitors: Design and simulation studies of the catalytic turnover

    Journal of the American Chemical Society, Vol. 135, Núm. 33, pp. 12366-12376

2012

  1. A nitro sugar-mediated stereocontrolled synthesis of β2- amino acids: Synthesis of a polyhydroxylated trans-2-aminocyclohexanecarboxylic acid

    European Journal of Organic Chemistry, pp. 2969-2979

  2. An overview of key routes for the transformation of sugars into carbasugars and related compounds

    Carbohydrate Chemistry, Vol. 38, pp. 263-302

  3. Studies on the Michael addition of naphthoquinones to sugar nitro olefins: First synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones

    Tetrahedron, Vol. 68, Núm. 5, pp. 1612-1621

2011

  1. A prodrug approach for improving antituberculosis activity of potent mycobacterium tuberculosis type II dehydroquinase inhibitors

    Journal of Medicinal Chemistry, Vol. 54, Núm. 17, pp. 6063-6084

  2. On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors

    Journal of Medicinal Chemistry, Vol. 54, Núm. 8, pp. 3081-3085

  3. Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of TypeII Dehydroquinase

    ChemMedChem, Vol. 6, Núm. 2, pp. 266-272

2010

  1. Effect of the protonation state of the titratable residues on the inhibitor affinity to BACE-1

    Biochemistry, Vol. 49, Núm. 34, pp. 7255-7263