Publicacións en colaboración con investigadores/as de University of Bari Aldo Moro (13)

2016

  1. 8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

    ChemistrySelect, Vol. 1, Núm. 11, pp. 2742-2749

  2. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

    Journal of Medicinal Chemistry, Vol. 59, Núm. 14, pp. 6791-6806

  3. Searching for multi-targeting neurotherapeutics against Alzheimer's: Discovery of potent AChE-MAO B inhibitors through the decoration of the 2H-Chromen-2-one structural motif

    Molecules, Vol. 21, Núm. 3

2015

  1. In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors

    European Journal of Medicinal Chemistry, Vol. 89, pp. 98-105

  2. Structure-Based Design and Optimization of Multitarget-Directed 2 H -Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

    Journal of Medicinal Chemistry, Vol. 58, Núm. 14, pp. 5561-5578

2013

  1. Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors

    Journal of Medicinal Chemistry, Vol. 56, Núm. 6, pp. 2651-2664

  2. Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors

    European Journal of Medicinal Chemistry, Vol. 70, pp. 723-739

2012

  1. 2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity

    Archiv der Pharmazie, Vol. 345, Núm. 8, pp. 598-609

2009

  1. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: Development and biopharmacological profiling of 7-[(3-chlorobenzyl) oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor

    Journal of Medicinal Chemistry, Vol. 52, Núm. 21, pp. 6685-6706

2008

  1. Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides

    Biochemical Pharmacology, Vol. 75, Núm. 7, pp. 1526-1537

2007

  1. Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives

    Journal of Medicinal Chemistry, Vol. 50, Núm. 22, pp. 5364-5371

2006

  1. Ester derivatives of annulated tetrahydroazocines: A new class of selective acetylcholinesterase inhibitors

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 21, pp. 7205-7212

  2. Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches

    Journal of Medicinal Chemistry, Vol. 49, Núm. 16, pp. 4912-4925