María Isabel
Loza García
University professor
![Foto de María Isabel](/img/uploaded/71A9B508C79AFAB78E38ABD10B96C498.jpg)
![Foto de Universitat Pompeu Fabra](/img/noimage_org.png)
Universitat Pompeu Fabra
Barcelona, EspañaPublications in collaboration with researchers from Universitat Pompeu Fabra (29)
2024
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G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
Nature communications, Vol. 15, Núm. 1, pp. 4307
2023
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A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry
Archives of Toxicology, Vol. 97, Núm. 4, pp. 1091-1111
2017
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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
European Journal of Pharmacology, Vol. 815, pp. 138-146
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Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes
Molecular Diversity, Vol. 21, Núm. 3, pp. 533-546
2016
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Open PHACTS computational protocols for: In silico target validation of cellular phenotypic screens: Knowing the knowns
MedChemComm, Vol. 7, Núm. 6, pp. 1237-1244
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
PLoS Pathogens, Vol. 12, Núm. 7
2015
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Detection of new biased agonists for the serotonin 5-ht2a receptor: modeling and experimental validation
Molecular Pharmacology, Vol. 87, Núm. 4, pp. 740-746
2014
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Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors
Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607
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Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles
European Journal of Medicinal Chemistry, Vol. 77, pp. 91-95
2013
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Scientific requirements for the next-generation semantic web-based chemogenomics and systems chemical biology molecular information system OPS
Computational Chemogenomics (Pan Stanford Publishing Pte. Ltd.), pp. 213-242
2012
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New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships
European Journal of Medicinal Chemistry, Vol. 54, pp. 303-310
2011
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Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT2A and D2 receptors in mice
Behavioural Pharmacology, Vol. 22, Núm. 4, pp. 362-369
2010
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A novel multilevel statistical method for the study of the relationships between multireceptorial binding affinity profiles and in vivo endpoints
Molecular Pharmacology, Vol. 77, Núm. 2, pp. 149-158
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Synthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D2and D3 receptors
ChemMedChem, Vol. 5, Núm. 8, pp. 1300-1317
2009
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Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands
Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 6, pp. 1773-1778
2008
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1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 6, pp. 2852-2869
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Corrigendum to "1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor" [Bioorg. Med. Chem. 16 (2008) 2852-2869] (DOI:10.1016/j.bmc.2008.01.002)
Bioorganic and Medicinal Chemistry
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Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics
Journal of Medicinal Chemistry, Vol. 51, Núm. 19, pp. 6085-6094
2007
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Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor
Journal of Medicinal Chemistry, Vol. 50, Núm. 14, pp. 3242-3255
2006
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Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor
Journal of Medicinal Chemistry, Vol. 49, Núm. 1, pp. 282-299