MARIA DE LOS ANGELES
CASTRO PEREZ
Senior university lecturer
Publications (60) MARIA DE LOS ANGELES CASTRO PEREZ publications
2024
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
Molecules, Vol. 29, Núm. 11
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Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening
ChemMedChem, Vol. 19, Núm. 14
2023
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Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia
Molecules, Vol. 28, Núm. 10
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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling
European Journal of Medicinal Chemistry, Vol. 252
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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation
Journal of enzyme inhibition and medicinal chemistry, Vol. 38, Núm. 1, pp. 2209828
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Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
International Journal of Molecular Sciences, Vol. 24, Núm. 18
2022
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Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications
Pharmacological Reports, Vol. 74, Núm. 2, pp. 406-424
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An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery
International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267
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Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties
Molecules, Vol. 27, Núm. 4
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In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1
Neurochemical Research, Vol. 47, Núm. 6, pp. 1778-1789
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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
ChemMedChem, Vol. 17, Núm. 15
2021
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327
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N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand
Neurochemistry International, Vol. 146
2020
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1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors
Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Biochemical Pharmacology, Vol. 177
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N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl]piperidine-4-carboxamide (d2aak4), a multi-target ligand of aminergic gpcrs, as a potential antipsychotic
Biomolecules, Vol. 10, Núm. 2
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New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation
Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530
2019
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2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships
Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558
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Phenolic imidazole derivatives with dual antioxidant/antifungal activity: Synthesis and structure-activity relationship
Medicinal Chemistry, Vol. 15, Núm. 4, pp. 341-351
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689