MARIA DE LOS ANGELES
CASTRO PEREZ
Profesora titular de universidade
María Isabel
Loza García
Catedrática de universidade
Publicacións nas que colabora con María Isabel Loza García (25)
2024
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
Molecules, Vol. 29, Núm. 11
2023
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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling
European Journal of Medicinal Chemistry, Vol. 252
2022
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An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery
International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267
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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
ChemMedChem, Vol. 17, Núm. 15
2021
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327
2020
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1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors
Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Biochemical Pharmacology, Vol. 177
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New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation
Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530
2019
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2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships
Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689
2017
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Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Scientific Reports, Vol. 7, Núm. 1
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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
European Journal of Pharmacology, Vol. 815, pp. 138-146
2016
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Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation
European Journal of Medicinal Chemistry, Vol. 112, pp. 258-269
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Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics
ChemMedChem, Vol. 11, Núm. 7, pp. 718-729
2014
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Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles
European Journal of Medicinal Chemistry, Vol. 77, pp. 91-95
2013
2012
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New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships
European Journal of Medicinal Chemistry, Vol. 54, pp. 303-310
2011
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Synthesis of novel chromene scaffolds for adenosine receptors
Organic and Biomolecular Chemistry, Vol. 9, Núm. 11, pp. 4242-4249
2010
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Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13
Biochemical Journal, Vol. 432, Núm. 3, pp. 451-459
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Phe369(7.38) at human 5-HT 7 receptors confers interspecies selectivity to antagonists and partial agonists
British Journal of Pharmacology, Vol. 159, Núm. 5, pp. 1069-1081