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MARIA ISABEL
CADAVID TORRES
Forscherin in der Zeit 1987-2022
Publikationen (49) Publikationen von MARIA ISABEL CADAVID TORRES
2020
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Biochemical Pharmacology, Vol. 177
2017
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Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
Journal of Medicinal Chemistry, Vol. 60, Núm. 17, pp. 7502-7511
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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Journal of Medicinal Chemistry, Vol. 60, Núm. 8, pp. 3372-3382
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Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A2B adenosine receptor antagonists
Chemistry of Heterocyclic Compounds, Vol. 53, Núm. 3, pp. 316-322
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Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease
Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 731-748
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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
European Journal of Pharmacology, Vol. 815, pp. 138-146
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Serotonin-2A homodimers are needed for signalling via both phospholipase A2 and phospholipase C in transfected CHO cells
European Journal of Pharmacology, Vol. 800, pp. 63-69
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Targeting PDE10A GAF domain with small molecules: A way for allosteric modulation with anti-inflammatory effects
Molecules, Vol. 22, Núm. 9
2016
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Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening
Journal of Biomolecular Screening, Vol. 21, Núm. 8, pp. 816-823
2015
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Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study
Neuroscience, Vol. 290, pp. 165-174
2014
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Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors
Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607
2013
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Discovery of 3,4-dihydropyrimidin-2(1 H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists
ACS Medicinal Chemistry Letters, Vol. 4, Núm. 11, pp. 1031-1036
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Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
European Journal of Medicinal Chemistry, Vol. 59, pp. 235-242
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Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of l-prolyl-l-leucyl-glycinamide (PLG) modified in the l-proline or l-proline and l-leucine scaffolds
European Journal of Medicinal Chemistry, Vol. 69, pp. 146-158
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The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling
Pharmacology Research and Perspectives, Vol. 1, Núm. 2
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Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities
European Journal of Medicinal Chemistry, Vol. 70, pp. 781-788
2012
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Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds
Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284
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Identification in Silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice
ACS Chemical Neuroscience, Vol. 3, Núm. 10, pp. 793-803
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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
European Journal of Medicinal Chemistry, Vol. 47, Núm. 1, pp. 175-185
2011
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Discovery of LAS101057: A potent, selective, and orally efficacious A 2B Adenosine Receptor Antagonist
ACS Medicinal Chemistry Letters, Vol. 2, Núm. 3, pp. 213-218