![Foto de FREDY SOLOMON](/img/nophoto.png)
FREDY SOLOMON
SUSSMAN
Researcher in the period 2018-2023
Publications (23) FREDY SOLOMON SUSSMAN publications
2024
-
The Diverse Nature of the Molecular Interactions That Govern the COV-2 Variants’ Cell Receptor Affinity Ranking and Its Experimental Variability
International Journal of Molecular Sciences, Vol. 25, Núm. 5
2019
-
Chain-Branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases
Pharmaceuticals, Vol. 12, Núm. 2
2018
-
Environmental Effects Determine the Structure of Potential β-Amino Acid Based Foldamers
Chemistry - A European Journal, Vol. 24, Núm. 42, pp. 10625-10629
2016
-
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease
ChemistrySelect, Vol. 1, Núm. 11, pp. 2742-2749
2015
-
Computer-aided structure-based design of multitarget leads for Alzheimer's disease
Journal of Chemical Information and Modeling, Vol. 55, Núm. 1, pp. 135-148
2013
-
Effect of pH and ligand charge state on BACE-1 fragment docking performance
Journal of Computer-Aided Molecular Design, Vol. 27, Núm. 5, pp. 403-417
2012
-
Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains
Chemistry - A European Journal, Vol. 18, Núm. 2, pp. 603-612
-
Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups
Bioorganic and Medicinal Chemistry, Vol. 20, Núm. 15, pp. 4838-4847
2011
-
On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors
Journal of Medicinal Chemistry, Vol. 54, Núm. 8, pp. 3081-3085
-
Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues hydroxymethylated at C-26
Journal of Medicinal Chemistry, Vol. 54, Núm. 11, pp. 3950-3962
2010
-
Effect of the protonation state of the titratable residues on the inhibitor affinity to BACE-1
Biochemistry, Vol. 49, Núm. 34, pp. 7255-7263
-
Studies on the stereocontrolled transformation of nitrohexofuranoses into 2-oxabicyclo[2.2.1]heptanes. V: Synthesis of enantiopure methyl (1R,2R,4S)-2-amino-4-hydroxycyclopentanecarboxylate
Tetrahedron Asymmetry, Vol. 21, Núm. 1, pp. 116-122
2009
-
Prediction and analysis of binding affinities for chemically diverse HIV-1 PR inhibitors by the modified SAFE-p approach
Journal of Computational Chemistry, Vol. 30, Núm. 8, pp. 1229-1240
-
Searching the conformational space of cyclic β-amino acid peptides
Journal of Physical Chemistry B, Vol. 113, Núm. 29, pp. 9669-9680
2008
-
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation
Journal of Medicinal Chemistry, Vol. 51, Núm. 4, pp. 852-860
-
Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. III: synthesis of enantiopure methyl (1S,2S,3R,4S,5R)-2-amino-3,4,5-trihydroxycyclopentanecarboxylate
Tetrahedron Asymmetry, Vol. 19, Núm. 24, pp. 2907-2912
2007
-
Inhibitor docking screened by the modified SAFE_p scoring function: Application to cyclic urea HIV-1 PR nhibitors
Journal of Computational Chemistry, Vol. 28, Núm. 13, pp. 2216-2225
-
The search for drug leads targeted to the β-secretase: An example of the roles of computer assisted approaches in drug discovery
Current Topics in Medicinal Chemistry, Vol. 7, Núm. 10, pp. 980-990
-
Total synthesis of (5S,6S)-6-amino-2,8-dimethylnonan-5-ol and (5S,6S)-6-amino-7-cyclohexyl-2-methylheptan-5-ol
Arkivoc, Vol. 2007, Núm. 4, pp. 380-388
2004
-
Predicting the Cell Differentiation Activity of 1α ,25-Dihydroxyvitamin D3 Side Chain Analogues from Docking Simulations
Journal of Medicinal Chemistry, Vol. 47, Núm. 7, pp. 1613-1616