I+D de fármacos
GI-1606
Universidade Do Porto
Oporto, PortugalPublikationen in Zusammenarbeit mit Forschern von Universidade Do Porto (109)
2023
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2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 38, Núm. 1
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8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies
European Journal of Medicinal Chemistry, Vol. 248
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Cytogenotoxicity assessment of 3-(3,4-dihydroxyphenyl)-7,8-dihydroxycoumarin on HepG2/C3A cells and leukocytes
Journal of Applied Toxicology, Vol. 43, Núm. 2, pp. 323-334
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In silico approaches to develop new phenyl-pyrimidines as glycogen synthase kinase 3 (GSK-3) inhibitors with halogen-bonding capabilities: 3D-QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies
Journal of Biomolecular Structure and Dynamics, Vol. 41, Núm. 22, pp. 13250-13259
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Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks
Journal of Medicinal Chemistry, Vol. 66, Núm. 3, pp. 1835-1851
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Oxidation-labile linkers for controlled drug delivery
Bioorganic and Medicinal Chemistry Letters, Vol. 87
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Phytochemical Analysis and Antiproliferative Activity of Ulex gallii Planch. (Fabaceae), a Medicinal Plant from Galicia (Spain)
Molecules, Vol. 28, Núm. 1
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Propargylamine: an important moiety in drug discovery
Future Medicinal Chemistry, Vol. 15, Núm. 1, pp. 211-224
2022
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A comprehensive ethnobotanical profile of Ocimum campechianum (Lamiaceae): from traditional medicine to phytochemical and pharmacological evidences
Plant Biosystems, Vol. 156, Núm. 6, pp. 1388-1404
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Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin
Molecules, Vol. 27, Núm. 3
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Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties
European Journal of Medicinal Chemistry, Vol. 239
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Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives
ChemMedChem, Vol. 17, Núm. 21
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Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in β-cyclodextrin complexes and combination with benznidazole
Arabian Journal of Chemistry, Vol. 15, Núm. 3
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Thiocoumarins: From the Synthesis to the Biological Applications
Molecules, Vol. 27, Núm. 15
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Treating neurodegenerative diseases with multitarget drugs: an interview with Maria João Matos
Future Medicinal Chemistry, Vol. 14, Núm. 12, pp. 847-850
2021
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3-phenylcoumarins as a privileged scaffold in medicinal chemistry: The landmarks of the past decade
Molecules, Vol. 26, Núm. 21
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4-Oxoquinolines and monoamine oxidase: When tautomerism matters
European Journal of Medicinal Chemistry, Vol. 213
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7-Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
ChemMedChem, Vol. 16, Núm. 1, pp. 179-186
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Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents
Arabian Journal of Chemistry, Vol. 14, Núm. 3
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Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors
Bioorganic Chemistry, Vol. 108