Publicacións nas que colabora con José Manuel Brea Floriani (24)

2023

  1. 8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies

    European Journal of Medicinal Chemistry, Vol. 248

2021

  1. 3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

    Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480

2017

  1. 3-Oxopyridazin-5-yl-Chalcone Hybrids: Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation

    ChemistrySelect, Vol. 2, Núm. 17, pp. 4920-4933

  2. Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

    Journal of Medicinal Chemistry, Vol. 60, Núm. 8, pp. 3372-3382

2014

  1. Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands

    European Journal of Medicinal Chemistry, Vol. 71, pp. 237-249

2013

  1. Discovery of 3,4-dihydropyrimidin-2(1 H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists

    ACS Medicinal Chemistry Letters, Vol. 4, Núm. 11, pp. 1031-1036

  2. Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold

    European Journal of Medicinal Chemistry, Vol. 59, pp. 235-242

  3. Synthesis and binding affinity of new 1,4-disubstituted triazoles as potential dopamine D3 receptor ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 20, pp. 5586-5591

2011

  1. Potential atypical antipsychotics: Synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

    MedChemComm, Vol. 2, Núm. 12, pp. 1194-1200

  2. Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists

    Journal of Medicinal Chemistry, Vol. 54, Núm. 2, pp. 457-471

2010

  1. Synthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D2and D3 receptors

    ChemMedChem, Vol. 5, Núm. 8, pp. 1300-1317

2009

  1. Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists

    Journal of Combinatorial Chemistry, Vol. 11, Núm. 4, pp. 519-522

  2. Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 21, pp. 6059-6062

  3. Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 6, pp. 1773-1778

2008

  1. Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics

    Journal of Medicinal Chemistry, Vol. 51, Núm. 19, pp. 6085-6094

2007

  1. Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor

    Journal of Medicinal Chemistry, Vol. 50, Núm. 14, pp. 3242-3255

  2. Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 17, Núm. 17, pp. 4873-4877

2006

  1. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine

    Neuropharmacology, Vol. 51, Núm. 2, pp. 251-262

2005

  1. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 15, Núm. 12, pp. 3063-3066

2004

  1. Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 14, Núm. 3, pp. 585-589