New supramolecular concepts for the development of functional systems in cells and protocells

Abstract

In this manuscript, we have approached the development of new functional supramolecular systems from a chemical perspective and with the objective to modify or replicate cellular functions. The main driving force of the three chapters of this work share a dynamic character of stimuli-responsive systems, which is crucial for their specific functional behaviour. The novel functional systems development focused on a protofilament cytoskeleton-mimetic system, a new ratiometric fluorescent SNARF probe with pH range sensitivity optimized and a pH sensitive antitumoral analogue of a natural venom.