Resección de GIST rectal mediante cirugía transanal mínimamente invasiva (TAMIS) tras neoadyuvancia con imatinib

  1. Fernando Fernández-López 1
  2. Maria Jesús Ladra-González 1
  3. Francisco González-Rodríguez 1
  4. Manuel Paz-Novo 1
  5. Jesús Paredes-Cotoré 1
  6. Manuel Bustamante-Montalvo 1
  1. 1 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

Revista:
Revista Colombiana de Cancerología

ISSN: 2346-0199 0123-9015

Año de publicación: 2018

Volumen: 22

Número: 4

Páginas: 176-179

Tipo: Artículo

DOI: 10.1016/J.RCCAN.2017.10.004 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Revista Colombiana de Cancerología

Objetivos de desarrollo sostenible

Resumen

Abstract The primary treatment of choice for patients with a localised gastro-intestinal stromal tumour (GIST) is complete surgical excision with negative microscopic margins. However, in a space as small as that of the pelvis, complete resection of a large rectal tumour is difficult, and sometimes requires an abdominoperineal amputation. In order to reduce the size of the tumour, as well as the morbidity associated with more aggressive surgical procedures, neoadjuvant treatment with Imatinib was introduced in this case, with the response being monitored by of endoscopic ultrasound. The response obtained by reducing the tumour volume modified the strategy, making it possible to obtain a satisfactory resection using transanal minimally invasive surgery (TAMIS), preserving the anal sphincters and avoiding the genitourinary morbidity associated with the mesorectal excision.

Referencias bibliográficas

  • Saund, MS,Demetri, GD,Ashley, SW. (2004). Gastrointestinal stromal tumors (GISTs). Curr Opin Gastroenterol. 20. 89-94
  • DeMatteo, RP,Lewis, JJ,Leung, D,Mudan, SS,Woodruff, JM,Brennan, MF. (2000). Two hundred gastrointestinal stromal tumors Recurrence patterns and prognosis factors for survival. Ann Surg. 231. 51
  • Kantawala, KP,Sonavane, SK,Menias, CO,Pai, RK. (2011). Atypical tumors of the rectum with pathologic correlation. Curr Probl Diagn Radiol. 40. 198-207
  • Blay, JY,Bonvalot, S. (2005). Casali P Choi H.Debiec-Richter M.Dei Tos AP Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol. 16. 566
  • Poveda, A,Artigas, V,Casado, A,Cervera, J. (2008). García del Muro X.López-Guerrero JA Guía de práctica clínica en los tumores estromales gastrointestinales (GIST) Actualización 2008. Cir Esp. 84. 1-12
  • (2017). National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network, Inc.
  • (2014). The ESMO European Sarcoma Network Working Group Gastrointestinal stromal tumours ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 25. 21
  • Joensuu, H,Vehtari, A,Riihimaki, T,Nishida, T. (2012). Steigen SE, Brabec P, et al Risk of recurrence of gastrointestinal stromal tumour after surgery: An analysis of pooled population-based cohorts. Lancet Oncol. 13. 265
  • Fernández, JA,Parrilla, P. (2009). Tratamiento quirúrgico del GIST avanzado en la era del imatinib. Cir Esp. 86. 3-12
  • Kyo, K,Azuma, M,Okamoto, K,Nishiyama, M,Shimamura, T,Maema, A. (2016). Neoadjuvant imatinib treatment and laparoscopic anus-preserving surgery for a large gastrointestinal stromal tumor of the rectum. World J Surg Oncol. 14. 68