Investigation of the influence of the membrane lipid environment on g protein-coupled receptor activation by molecular dynamics simulations
- BRUZZESE NOVOA, AGUSTIN ALBERTO
- James Andrew Rupert Dalton Director
- Jesus Giraldo Arjonilla Co-director
Defence university: Universitat Autònoma de Barcelona
Fecha de defensa: 24 February 2021
- M. Isabel Loza García Chair
- Jean-Didier Maréchal Secretary
- Jana Selent Committee member
Type: Thesis
Abstract
G-protein-coupled receptors (GPCRs) are important therapeutic targets for numerous diseases. Although GPCRs have been extensively studied in recent decades, the molecular mechanisms that determine their activation as well as their allosteric modulation by membrane lipids have not been fully elucidated. This thesis examines the processes of (de)activation of two prototypical class A GPCRs, β2-adrenergic and adenosine A2a receptors, in membranes of different lipid composition by means of molecular dynamics simulations.