Impacto de las alteraciones genéticas en la clasificación y pronóstico del Linfoma B de alto grado

  1. González de Villambrosia Pellón, Sonia
Supervised by:
  1. Santiago Montes Moreno Director
  2. Eulogio Conde García Director

Defence university: Universidad de Cantabria

Fecha de defensa: 03 June 2022

Committee:
  1. Javier León Serrano Chair
  2. Máximo F. Fraga Rodríguez Secretary
  3. Eva González Barca Committee member

Type: Thesis

Teseo: 724336 DIALNET lock_openUCrea editor

Abstract

High Grade B Cell Lymphoma, NOS, and High Grade B Cell Lymphoma with Dual Hit or Triple Hit have been recently recategorized in the 2016 revision of the WHO classification of lymphoid neoplasms. In this study we have characterized the genetic, histopathological, and clinical features of a series of this type of lymphoid neoplasia (17 HGBCL NOS and 53 HGBCL DH/TH). HGBCL NOS showed better response to first line treatment than HGBCL with DH/TH but no significant differences in PFS or OS were found between the two categories. Survival analysis in the whole cohort of cases found that only the presence of BCL2 translocation was significantly associated with PFS. Other clinical features such as IPI, LDH or stage were equivalent in both categories. Furthermore, both high grade and DLBCL morphological patterns showed equivalent PFS and OS in this set of High grade BCL NOS/DH/TH.