Quantification methods of PET biomarkers in Alzheimers disease

  1. Francisco Javier López González
Dirigida por:
  1. Pablo Aguiar Fernández Director
  2. Jesús Silva Rodríguez Director/a

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 22 de marzo de 2023

Tribunal:
  1. Michel Grothe Presidente/a
  2. Pascual Sánchez-Juan Secretario/a
  3. Valle Camacho Martí Vocal
Departamento:
  1. Departamento de Psiquiatría, Radiología, Salud Pública, Enfermería y Medicina

Tipo: Tesis

Teseo: 799733 DIALNET lock_openMINERVA editor

Resumen

PET studies with 18F-Fluorodesoxiglucosa, 18F-Florbetapir and 18FFlortaucipir radiotracers have become as the reference techniques to generate the neurodegeneration biomarkers, amyloidosis and taupathy needed in a reliable diagnosis and the staging of the Alzheimers disease. Nevertheless, in order to measure these biomarkers in a precise and reproducible manner, it is necessary to develop PET image quantification methods. The objective of this thesis is to implement and to validate different methods that improve the PET image quantification by using Monte Carlo simulation techniques. The main problems with the quantification methods of PET biomarkers, such as the election of a suitable reference region, intensity normalization and partial volume effects are addressed.