New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles
- Velasco Rubio, Álvaro
- Carlos Saa Rodríguez Director
- Jesus Angel Varela Carrete Director
Defence university: Universidade de Santiago de Compostela
Fecha de defensa: 03 December 2021
- José Luis Mascareñas Cid Chair
- Mercedes Amat Tusón Secretary
- Igor Larrosa Guerrero Committee member
Type: Thesis
Abstract
Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main challenge to the organic chemistry. In this thesis the synthesis of these three nuclei upon generation of a key metalp- allyl intermediate through Csp2-H activation, allylic C-H activation, and Rh-hydride catalysis have been successfully accomplished.