New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles

  1. Velasco Rubio, Álvaro
Supervised by:
  1. Carlos Saa Rodríguez Director
  2. Jesus Angel Varela Carrete Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 03 December 2021

Committee:
  1. José Luis Mascareñas Cid Chair
  2. Mercedes Amat Tusón Secretary
  3. Igor Larrosa Guerrero Committee member
Department:
  1. Department of Organic chemistry

Type: Thesis

Abstract

Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main challenge to the organic chemistry. In this thesis the synthesis of these three nuclei upon generation of a key metalp- allyl intermediate through Csp2-H activation, allylic C-H activation, and Rh-hydride catalysis have been successfully accomplished.