Utilización del polietilenglicol con electrólitos en niños menores de 2 añosDosificación, eficacia y tolerancia. Estudio de 35 pacientes

Abstract

Aim: To evaluate the efficacy, tolerance and optimal dose of PEG 3350 with electrolytes for treatment of functional constipation in patients younger than 24 months. Patients and methods: Reviewed the charts patients with functional constipation (Rome III criteria) treated with PEG orally. PEG was administered mixed in the bottle or diluted in fluids, using 1/2 sachet/day in younger than 12 months and 1 sachet/day in older than 12 months. Initial and effective maintenance dose, number of stools per week and stool consistency before and after treatment, duration and the side effects of treatment were recorded. Results: Thirty-five patients (19 female and 16 male) were identified. Mean age was 13.64 ± 6.10 months, mean weight 11.65 ± 2.72 kg. Mean duration of treatment was 4.6 ± 3.67 months. Mean initial dose was 0.43 ± 0.26 g/kg/day and mean effective maintenance dose was 0.57 ± 0.34 g/kg/day. There was a significant difference in the number of stools per week and in the stool consistency score after treatment (p <0.001). PEG relieved constipation in 97.14% of patients (n= 34) after 12 weeks of treatment. Adverse events included 5 patients (14.2%), resolved after adjusting the dose. Conclusions: Acceptance, compliance and adherence of families to treatment was very good. Average effective dose was 0.57 g/kg/day. There was a significant difference in the number of stools per week and in the stool consistency score before versus after treatment (p <0.001). Adverse effects were resolved after adjusting the dose. PEG with electrolytes is safe, well tolerated and highly effective in the management of constipation for patients younger than 24 months.