Supramolecular strategies for intracellular delivery and design of new thermoresponsive materials

  1. Fernández Caro, Héctor
Supervised by:
  1. Juan Ramón Granja Guillán Director
  2. Javier Montenegro García Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 18 December 2020

Committee:
  1. Ramón Eritja Casadellà Chair
  2. Pablo Alfonso del Pino González de la Higuera Secretary
  3. Olalla Vázquez Vázquez Committee member
Department:
  1. Department of Organic chemistry

Type: Thesis

Teseo: 642000 DIALNET lock_openMINERVA editor

Abstract

In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to encapsulate and deliver different anionic probes such as pyranine, as well as anionic peptides with low self-delivery efficiency. Finally, we have designed potential thermoresponsive supramolecular materials based on self-assembling cyclic peptide nanotubes (SCPNs).