In vivo reprogramming of ischemic brain as a new therapeutical way in the ischemic stroke

  1. López Loureiro, Ignacio José
unter der Leitung von:
  1. José Antonio Castillo Sánchez Doktorvater
  2. Francisco Campos Pérez Co-Doktorvater/Doktormutter
  3. Tomas Sobrino Moreiras Co-Doktorvater/Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 07 von Februar von 2020

Gericht:
  1. Isabel Rodríguez-Moldes Präsidentin
  2. Mar Castellanos Rodrigo Sekretär/in
  3. Alba Vieites Prado Vocal
Fachbereiche:
  1. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Art: Dissertation

Teseo: 607353 DIALNET lock_openMINERVA editor

Zusammenfassung

Ischemic stroke is the main cause of disability and an immense burden both on the resources of families and societies. Actual treatments are neuroprotective therapies only available for 3-7% of stroke patients. Consequently, new therapies are necessary to reduce the impact of ischemic stroke. In this Thesis we hypothesized that is possible to reprogram astrocytes to neurons using siRNAs for the inhibition of NOTCH1 pathway. This strategy could allow to reprogram astrocytes of the glial scar as a suitable treatment for the ischemic stroke. Therefore, we tested this treatment in an animal model of ischemic stroke. We also hypothesized that this treatment could be delivered in a tranlational way by the used of biodegradable non-toxic particles.