Optimization of thrombolytic therapy in brain pathology

  1. Correa Paz, Clara
Dirixida por:
  1. Francisco Campos Pérez Director
  2. Tomas Sobrino Moreiras Director
  3. José Antonio Castillo Sánchez Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 28 de novembro de 2019

Tribunal:
  1. Ignacio Lizasoain Hernández Presidente/a
  2. Pablo Hervella Lorenzo Secretario/a
  3. Marina Rubio Gómez Vogal
Departamento:
  1. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Tipo: Tese

Teseo: 605519 DIALNET lock_openMINERVA editor

Resumo

Ischemic stroke is the leading cause of disability in the developed countries. The only approved drug treatment is the recombinant tissue plasminogen activator (rtPA). However, its use is limited due to the short half-life side effects. In this study we have developed rtPA-loaded nanocapsules combined with ultrasound application, which we used as trigger to induce rtPA from our nanocapsules. These nanocapsules were also able to extend the half-life of rtPA after in vivo administration and reach the ischemic region. Overall, we have developed promising nanocapsules for the triggered release of rtPA in the brain with potential application in ischemic stroke.