Oral mucosal peeling related to dentifrices and mouthwashesa systematic review

  1. Daniel Pérez López 1
  2. Pablo Ignacio Varela Centelles 2
  3. María José García Pola 3
  4. Pablo Castelo Baz 1
  5. Lucía García-Caballero Pérez 1
  6. Juan M. Seoane Romero 3
  1. 1 Dept of Surgery & Medical-Surgical Specialities. School of Medicine & Dentristry. University of Santiago de Compostela
  2. 2 Dept of Surgery & Medical-Surgical Specialities. School of Medicine & Dentristry. University of Santiago de Compostela; CS Praza do Ferrol. EOXI Lugo, Cervo, e Monforte. Servizo Galego de Saúde. Lugo. Spain
  3. 3 Dept of Surgery & Medical-Surgical Specialities. School of Medicine & Health Sciences. University of Oviedo. Spain
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Ano de publicación: 2019

Volume: 24

Número: 4

Páxinas: 15

Tipo: Artigo

DOI: 10.4317/MEDORAL.22939 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa


The aim of this systematic review was to summarise the clinical information available about oral mucosal peeling (OMP) and to explore its aetiopathogenic association with dentifrices and mouthwashes. PICOS outline: Population: subjects diagnosed clinically and/or pathologically. Intervention: exposition to oral hygiene products. Comparisons: patients using products at different concentrations. Outcomes: clinicopathological outcomes (primary) and oral epithelial desquamation (secondary) after use. Study design: any. Exclusion criteria: reports on secondary or unpublished data, in vitro studies. Data were independently extracted by two reviewers. Fifteen reports were selected from 410 identified. Descriptive studies mainly showed low bias risk, experimental studies mostly an “unclear risk”. Dentifrices or mouthwashes were linked to OMP, with an unknown origin in 5 subjects. Sodium lauryl-sulphate (SLS) was behind this disorder in 21 subjects, tartar-control dentifrices in 2, and flavouring agents in 1 case. Desquamation extension was linked to SLS concentration. Most cases were painless, leaving normal mucosa after desquamation. Tartar-control dentifrices caused ulcerations more frequently. OMP management should consider differential diagnosis with oral desquamative lesions, particularly desquamative gingivitis, with a guided clinical interview together with pathological confirmation while discouraging the use of the product responsible for OMP.

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