Indicaciones, secuencia e interpretación de las pruebas funcionales adrenales

  1. C. Guillín 1
  2. I. Bernabeu 1
  3. E. Fernández-Rodríguez 2
  4. F.F. Casanueva 1
  1. 1 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

  2. 2 Servicio de Endocrinología y Nutrición. Complejo Hospitalario de Ourense. Orense. España
Revista:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Año de publicación: 2016

Título del ejemplar: Enfermedades endocrinológicas y metabólicas (II) Patología suprarrenal

Serie: 12

Número: 14

Páginas: 802-810

Tipo: Artículo

DOI: 10.1016/J.MED.2016.06.014 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Medicine: Programa de Formación Médica Continuada Acreditado

Objetivos de desarrollo sostenible

Resumen

Introduction In this work we summarize the functional tests indicated in the most frequent adrenal pathology: corticotrop axis, renin-angiotensin-aldosterone system and catecholamines production. Basis and indications The altered adrenal can be hyper or hypoactive; atrophic, hyperplastic or carrying a tumor. Functional studies aim to determine the existence of hyper– or hypofunction in any of the endocrine systems of the body and, somehow, to locate the point which has lost the normal control. In general, a stimulus test is performed when we suspect a loss of function, and, conversely, an inhibition test is performed when we suspect a gain of function.

Referencias bibliográficas

  • Alfayate R, Fajardo C, González-Clemente JM. Diagnóstico de laboratorio en endocrinología. Madrid: Nature Publishing Group Iberoamérica; 2015.
  • Eisenhofer G, Goldstein DS, Walther MM, Friberg P, Lenders JW, Keiser HR, et al. Biochemical diagnosis of pheochromocytoma: how to distinguish true from false-positive test results. J Clin Endo-crinol Metab. 2003;88(6):2656-66. 32.
  • Eisenhofer G, Lenders JVM, Timmers H, Mannelli M, Grebe SK, Hofbauer LC, et al. Measurements of plasma methoxytiranmi-ne, normetanephrine and metanephrine as discriminators of diffe-rent hereditary forms of phechromocytoma. Clin Chem. 2011;57(3):411-20.
  • Funder JW, Carey RM, Fardella C, Gómez-Sánchez CE, Man-tero F, Stowasser M, et al. Case detection, diagnosis, and treatment of patientswithprimaryaldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008;93(9):3266-81.
  • Kazlauskaite R, Evans AT, Villabona CV, Abdu TA, Ambrosi B, Atkinson AB, et al. Consortium for evaluation of corticotropin test in hypothalamic-pituitary adrenal insufficiency. Corticotropin tests for hypothalamic-pituitary– adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab. 2008;93(11):4245-53.
  • Kronenberg HM, Melmed S, Polonsky KS, Larsen R. Williams tratado de endocrinología. 11ª ed. Barcelona: Elsevier Saunders; 2009.
  • Nanba K, Tamanaha T, Nakao K, Kawashima ST, Usui T, Tagami T, et al. Confirmatory testing in primary aldosteronism. J Clin En-docrinol Metab. 2012;97(5):1688-94.
  • Rossi GP, Belfiore A, Bernini G, Desideri G, Fabris B, Ferri C, et al. Prospective evaluation of thesaline infusion test for excluding primary aldosteronismdue to aldosterone-producing adenoma. J Hypertens. 2007;25(7):1433-42.
  • Salvà M, Cicala MV, Mantero F. Primary aldosteronism: the role of confirmatorytests. Horm Metab Res. 2012;44(3):177-80.
  • Van Berkel A, Lenders JW, Timmers HJ. Diagnosis of endocri-ne disease: biochemical diagnosis of phaeochromocytoma and para-ganglioma. Eur J Endocrinol. 2014;170(3):R109-19.
  • Willemsen JJ, Ross HA, Lenders JW, Sweep FC. Stability of uri-nary fractionated metanephrines and catecholamines duringc ollec-tion, shipment, and storage of samples. ClinChem. 2007;53(2):268-72.