Estimulación cerebral profunda. Una alternativa a la cirugía bariátrica.

Abstract

Obesity has become one of the greatest threats to global public health in the new millennium. Most surgical interventions for obesity have focused on modifying the anatomy of the alimentary tract and include gastric bypass, gastric banding and intragastric balloon placement. Despite reductions in mortality rates, weight gain may occur following bariatric surgery due to dietary relapse. High-frequency deep brain stimulation is the treatment of Choice for well selected patients with medically refractory movement disorders. The success of deep brain stimulation in relieving parkinsonism has led to its application in multiple neurological diseases and more recently to treatment psychiatric condition (depression and obsessive compulsive disorders). We revised the literature implicating various neural regions in the pathophysiology of obesity, as well as the evidence supporting these regions as targets for deep brain stimulations, in order to explore the therapeutic promise of brain stimulation in obesity.