Epidemiología molecular del virus de la hepatitis C en Galiciaprevalencia y distribución de los genotipos virales en el área sanitaria de Santiago de Compostela

Abstract

We retrospectively analyzed a total of 1815 chronically infected HCV patients. The median age was 50 years (IQR, 57-45), 72,5% were male, 1,8% were immigrants, 38,9% were HBV coinfected and 16,6% were HIV coinfected. The main route of transmission was parenteral (86,3%) followed by unknown (12,0%), among the parenteral infections, 65,7% cases were IDUs and 33,4% cases were associated with unsafe medical procedures. Genotype distribution was: 61,7% genotype 1 (28,2% subtype 1a and 32,8% subtype 1b,) 3,2% genotype 2, 20,3% genotype 3, 14,7% genotype 4, and 0,1% genotype 5. Subtype 1a and genotype 4 were significantly associated with IDUs, coastal area, men and coinfection by HBV and HIV, while genotype 3 only made with IDU and coastal area. In contrast, subtype 1b was significantly associated with women, rural area, unsafe medical procedures, unknown risk factor and monoinfection. In addition, an age effect was observed in the distribution of genotypes. No significant difference was seen in the progression to cirrhosis among different genotypes, but a significant association subtype 1b is observed with the development of HCC. In free-IFN therapies, SVR of 97.3% was obtained regardless of genotype and previous treatment failures