Publicacións (10) Publicacións de MANUEL MARIA PAZ CASTAÑAL

filter_list Pharmacology

2023

  1. Insight Into Factors Governing Formation, Synthesis and Stereochemical Configuration of DNA Adducts Formed by Mitomycins

    Chemical Record, Vol. 23, Núm. 1

2019

  1. Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts

    Bioorganic Chemistry, Vol. 92

2018

  1. Interdependent Sequence Selectivity and Diastereoselectivity in the Alkylation of DNA by Decarbamoylmitomycin C

    Chemistry - A European Journal, Vol. 24, Núm. 50, pp. 13278-13289

  2. Isolation and Rationale for the Formation of Isomeric Decarbamoylmitomycin C- N6-deoxyadenosine Adducts in DNA

    Chemical Research in Toxicology, Vol. 31, Núm. 8, pp. 762-771

  3. Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C

    Chemistry - A European Journal, Vol. 24, Núm. 23, pp. 6030-6035

2016

  1. Synthesis of Mitomycin C and Decarbamoylmitomycin C N2 deoxyguanosine-adducts

    Bioorganic Chemistry, Vol. 65, pp. 90-99

2009

  1. Reductive activation of mitomycin C by thiols: Kinetics, mechanism, and biological implications

    Chemical Research in Toxicology, Vol. 22, Núm. 10, pp. 1663-1668

2002

  1. Relative toxicities of DNA cross-links and monoadducts: New insights from studies of decarbamoyl mitomycin C and mitomycin C

    Chemical Research in Toxicology, Vol. 15, Núm. 11, pp. 1398-1406

2001

  1. Reductive activation of mitomycin A by thiols

    Organic Letters, Vol. 3, Núm. 18, pp. 2789-2792

  2. Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: Biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential

    Journal of Medicinal Chemistry, Vol. 44, Núm. 17, pp. 2834-2842