Publicacións (22) Publicacións de MARIA OLGA CAAMAÑO SANTOS

filter_list Drug Discovery

2020

  1. Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

    Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739

2019

  1. Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition

    Journal of Medicinal Chemistry, Vol. 62, Núm. 20, pp. 9315-9330

2017

  1. Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists

    Journal of Medicinal Chemistry, Vol. 60, Núm. 17, pp. 7502-7511

2016

  1. Novel l-prolyl-l-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R

    Organic and Biomolecular Chemistry, Vol. 14, Núm. 47, pp. 11065-11069

2011

  1. Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists

    Journal of Medicinal Chemistry, Vol. 54, Núm. 2, pp. 457-471

2010

  1. Design, synthesis, and evaluation of antineoplastic activity of novel carbocyclic nucleosides

    Molecular Informatics, Vol. 29, Núm. 3, pp. 213-231

  2. Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 5, pp. 2001-2009

2009

  1. 1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 10, pp. 3618-3629

  2. Synthesis and biological evaluation of 6-substituted purinylcarbanucleosides with a cyclopenta[b]thiophene pseudosugar

    Synthesis, pp. 2766-2772

  3. Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A2B receptor antagonists

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 9, pp. 3426-3432

2008

  1. Synthesis and antiviral activities of novel purinyl- and pyrimidinyl-carbanucleosides derived from indan

    Synthesis, pp. 1845-1852

  2. Synthesis of novel purinyl-1′-homocarbanucleosides based on a cyclopenta[b]pyrazine system

    Chemical and Pharmaceutical Bulletin, Vol. 56, Núm. 5, pp. 654-658

2007

  1. Synthesis and evaluation of adenosine antagonist activity of a series of [1,2,4]triazolo[1,5-c]quinazolines

    Chemical and Pharmaceutical Bulletin, Vol. 55, Núm. 3, pp. 372-375

2004

  1. Synthesis and biological evaluation of carbocyclic nucleosides with 2′,3′-dihomo-xylo-carbocyclic or carbocyclic fused to a tetrahydrofuran ring

    Synthesis, pp. 1991-1995

2003

  1. Carbocyclic analogues of nucleosides from bis-(hydroxymethyl)-cyclopentane: Synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues

    Chemical and Pharmaceutical Bulletin, Vol. 51, Núm. 9, pp. 1060-1063

2002

  1. Synthesis of series of 1- and 3-differently substituted xanthines from imidazoles

    Chemical and Pharmaceutical Bulletin, Vol. 50, Núm. 10, pp. 1379-1382

  2. Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues

    Nucleosides, Nucleotides and Nucleic Acids, Vol. 21, Núm. 3, pp. 243-255

2000

  1. Synthesis of (1R, 3R)-3-[2-(aminoethyl)-2,2-dimethylcyclobutyl]methanol and (1S,3R)-(3-amino-2,2-dimethylcyclobutyl)methanol from (+)-nopinone

    Synthesis, pp. 1459-1463

1999

  1. Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues

    Nucleosides and Nucleotides, Vol. 18, Núm. 10, pp. 2253-2263

  2. Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity

    Nucleosides and Nucleotides