Fabrication of microfluidic devices with optical technologies that can contribute to the development of personalized therapies

Resumo

This thesis focuses on the development of microfluidic platforms employing advanced optical technologies for in vitro studies, aimed at improving personalized therapies. It addresses the discrepancy between standard static in vitro experiments and clinical outcomes by creating more physiological environments for cellular studies. To achieve this, various laser-based technologies will be studied in depth, including pulsed laser ablation, subaquatic indirect laser ablation, and stereolithographic 3D printing, emphasizing the advantages they offer over conventional methodologies in the manufacturing processes. Several microfluidic platforms will be developed using laser technologies, which will be tested and applied in the biomedical field, highlighting the great potential of merging both worlds.