Nanopartículas de oro para terapia del cáncersíntesis de ligandos carboránicos

Resumo

A key goal in oncology is to develop a method capable of selectively destroying malignant cells to treat cancer patients. Boron Neutron Capture Therapy (BNCT) is a binary therapy that consist of the administration of a compound containing 10B followed by irradiation with a neutron beam, which causes a nuclear fission reaction that selectively destroys tumor cells without harming healthy cells in the environment. The development of BNCT depends primarily on the availability of compounds that incorporate boron atoms and have an affinity for tumor receptors. Gold nanoparticles (AuNPs) can be used as vehicles in the transport and selective delivery of drugs to combat the disadvantages presented by conventional delivery. AuNPs are neither toxic nor immunogenic and are more inert to metabolization. The purpose of this work is the synthesis of AuNPs thar incorporate carboranic ligands as a source of boron of potential interest in treatment of tumors by BNCT. The synthesis of two carboranic ligands was carried out, one of which was bound to a sizedefined AuNPs.